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EDARBI: Proof of performance

When scientists compared EDARBI® (azilsartan medoxomil) with BENICAR® (olmesartan) and DIOVAN® (valsartan) for 6 weeks, they found that EDARBI lowered blood pressure better. In fact, they found that EDARBI lowered blood pressure about 31% more than BENICAR and about 57% more than DIOVAN. You can see the difference in systolic blood pressure (SBP, the top number) in the chart. Scientists use SBP numbers to measure heart disease risk because SBP continues to rise throughout your lifetime, while diastolic blood pressure (DBP, the bottom number) decreases. As high blood pressure and age are related, SBP is an accurate reflection of heart disease and stroke risk.


EDARBI 80 mg vs BENICAR 40 mg
in clinic SBP reduction at week 6:
−14.9 mm Hg vs −11.4 mm Hg


EDARBI 80 mg vs DIOVAN 320 mg
in clinic SBP reduction at week 6:
−14.9 mm Hg vs −9.5 mm Hg

Study design: A 6-week, randomized, double-blind, placebo- and active- controlled, forced-titration study in patients (N=1,291) with clinic SBP ≥150 mm Hg and ≤180 mm Hg and 24-hour mean SBP ≥130 mm Hg and ≤170 mm Hg. There was a 3- to 4-week washout period. Placebo lowered clinic SBP by 1.8 mm Hg (baseline SBP 156.3 mm Hg, n=148). The primary endpoint was change in 24-hour mean ambulatory SBP reduction at week 6.

While numbers don't tell the whole story, it's important to know that experts say that lowering your blood pressure is important in reducing your risk of heart disease and stroke. For example, the American Heart Association says that a 10 mm Hg reduction in SBP can lower your risk of death from stroke by 50% to 60%, and lower your risk of death from heart disease by 40% to 50%.

Medicines like EDARBI are very useful for reducing high blood pressure (hypertension). However, most people find that reaching their goal also means that they need to make lifestyle changes to improve their overall health and reduce their risk of heart attack and stroke. Talk with your doctor to find out more about what kind of treatment plan may work best for you.

Important Safety Information

WARNING: EDARBI and EDARBYCLOR can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.

  • Before taking EDARBI or EDARBYCLOR, tell your doctor if you are breastfeeding or plan to breastfeed. Discuss with your doctor other ways to lower your blood pressure. Breastfeeding while taking EDARBI or EDARBYCLOR is not recommended.
  • Do not take EDARBYCLOR if you make less urine because of kidney problems (anuria).
  • Do not take aliskiren-containing products with EDARBI or EDARBYCLOR if you have diabetes.
  • Tell your doctor about all your medical conditions, including if you have heart problems or stroke, have gout, or have liver or kidney problems. Kidney problems may become worse in people that already have kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose or may need to stop treatment with EDARBYCLOR. During treatment with EDARBI or EDARBYCLOR, certain people who have severe heart failure, narrowing of the artery to the kidney, or who lose too much body fluid such as with nausea, vomiting, bleeding, or trauma, may develop sudden kidney failure and in rare instances, death.
  • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other medicines to treat your high blood pressure or heart problem; water pills (diuretics); lithium; or digoxin.
  • EDARBI and EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension) which may cause you to feel faint or dizzy. Vomiting and diarrhea, a low salt diet, sweating a lot, or not drinking enough fluid can also lead to low blood pressure.
  • If you feel faint or dizzy, lie down and call your doctor right away. If you pass out (faint), have someone call your doctor or get medical help. Stop taking EDARBYCLOR.
  • If you have fluid and body salt (electrolyte) problems, tell your doctor if you experience any of the following symptoms: dry mouth, confusion, thirst, lack of energy (lethargic), weakness, drowsiness, passing very little urine or passing large amounts of urine, seizures, muscle pain/cramps, restlessness, muscle tiredness (fatigue), fast or abnormal heartbeat, nausea and vomiting, or constipation.
  • People who have increased levels of uric acid in the blood may develop gout. If you already have gout, tell your doctor about worsening of your gout symptoms.
  • In clinical studies, the most common side effect seen with EDARBI was diarrhea (2.0%).
  • In a clinical study, the side effects seen with EDARBYCLOR included dizziness (8.9%) and tiredness (2.0%).

Please talk to your healthcare professional and see complete Prescribing Information for EDARBI and EDARBYCLOR.

You are encouraged to report side effects of prescription drugs to Arbor Pharmaceuticals, LLC Medical Information at 1-866-516-4950 or to the FDA at or call 1-800-FDA-1088.


EDARBI and EDARBYCLOR are prescription medicines used to treat high blood pressure (hypertension). Your doctor may prescribe other medicines for you to take along with EDARBI or EDARBYCLOR to treat your high blood pressure. EDARBYCLOR is used when one medicine is not enough or as the first medicine if your doctor decides you are likely to need more than one medicine. Medicines that lower your blood pressure may lower your chances of having a stroke or heart attack, but they don't work alone. They should be part of a complete treatment plan.