Take control with a
Powerful
ARB + diuretic

Take control with a
Powerful ARB + diuretic

EDARBYCLOR® (azilsartan medoxomil/chlorthalidone) is 2 medicines in 1 to help you get to goal. If one medication is not enough or if you need more than one medicine to reach your blood pressure goal, EDARBYCLOR may be a good fit for you.1 EDARBYCLOR combines the same active ingredient in EDARBI®, azilsartan medoxomil, with the diuretic (“water pill”) chlorthalidone. The ARB in EDARBYCLOR works by relaxing blood vessels, and the diuretic works in the kidneys to help flush excess water and salt (sodium) from the body. Together, these 2 medicines help to lower blood pressure.1 

Abbreviation: ARB, angiotensin II receptor blocker
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Actual Patient

I’m not just 169/96.

I’m Glenn.

Every day, people like you are taking control of their high blood pressure with EDARBI and EDARBYCLOR.
See Their Stories

EDARBYCLOR outperforms Similar
Medication in Studies.2*

When scientists compared EDARBYCLOR 40/25 mg with Benicar HCT® (olmesartan medoxomil-hydrochlorothiazide) 40/25 mg for 12 weeks, they found that EDARBYCLOR lowered blood pressure better.2

In fact, EDARByclor demonstrated:

14.5% greater reduction

than Benicar HCT

(-42.5 mm Hg vs -37.1 mm Hg).2

This is important because millimeters matter.
Even a reduction of 2 to 5 mm Hg in your systolic blood pressure may lower your cardiovascular risk.3,†

Proper medical treatment and control has been shown to lower the risk of dying from heart-related problems such as heart attack and stroke.4†

*Based on clinical trial data vs Benicar HCT® (olmesartan medoxomil-hydrochlorothiazide).2
† CV risk reduction with EDARBI and EDARBYCLOR has not been established.

See Study Design

EDARBYCLOR Is Effective for
African American Patients1,5

From a subgroup analysis of the same clinical trial, another benefit of EDARBYCLOR was discovered: It is especially effective at lowering blood pressure among African American patients with high blood pressure.5

EDARByclor demonstrated:

18% greater SBP reduction

than Benicar HCT5*

EDARBYCLOR: -39.3 mm Hg
Benicar HCT: -33.3 mm Hg

This is important because common treatments such as renin angiotensin system (RAS) inhibitors are generally less effective in low-renin populations, including African Americans.6 EDARBYCLOR provides a choice for these populations.5

*Based on clinical trial data vs Benicar HCT, comparing 40/25 dose of EDARBYCLOR to 40/25 mg dose of Benicar HCT among African American participants.5

See Study Design
EDARBYCLOR Safety and Tolerability
Demonstrated safety profile1
EDARBYCLOR Safety
and Tolerability
Demonstrated safety profile1

Clinical studies of more than 3,900 people taking EDARBYCLOR found that side effects of the medication were generally mild and transient in nature:

Dizziness in up to 8.9%.1
Fatigue in up to 2.0%.1

Your doctor may monitor the potassium and creatinine levels in your blood while you’re taking EDARBYCLOR.1

EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension), which may cause dizziness or feeling faint.1

Vomiting and diarrhea, a low-salt diet, sweating a lot, or not drinking enough fluids can also lead to low blood pressure.1

If you are taking EDARBYCLOR and experience side effects that concern you, call your doctor for medical advice. You are encouraged to report side effects of prescription drugs to Azurity Pharmaceuticals, Inc. Medical Information at 1-866-516-4950 or to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

EDARBYCLOR
Recommended Dosing
The only ARB fixed-dose combination with chlorthalidone1
EDARBYCLOR Recommended
Dosing
The only ARB fixed-dose combination with chlorthalidone1

EDARBYCLOR is a once-daily oral medication that can help you achieve your blood pressure goals.1

  • May be administered with or without food.
  • May be administered with other antihypertensive agents.
  • Dose may be increased to 40/25 mg after 2 to 4 weeks as needed to achieve BP goals.
  • Correct volume depletion in patients prior to use.
  • Doses above maximum are probably not useful.
40/12.5 mg Once Daily
Starting dose
40/25 mg Once Daily
Maximal dose
Pills are not shown at actual size.

Lower Your BP Numbers, Lower Your Prescription Costs

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EDARBI®
(azilsartan
medoxomil)
Take control with a powerful ARB8

EDARBI is an effective choice for blood pressure control. EDARBI may be used as a single therapy or in combination with other blood pressure medications.7
Learn about EDARBI
  • 1. Edarbyclor [package insert]. Woburn, MA: Azurity Pharmaceuticals, Inc; 2022.
  • 2. Cushman WC, Bakris GL, White WB, et al. Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension. Hypertension. 2012;60(2):310-318. 
  • 3. Stamler R. Implications of the INTERSALT study. Hypertension. 1991;17(1 Suppl):I16-20.
  • 4. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269-1324.
  • 5. Ferdinand KC, Bakris GL, Cushman WC, et al. Comparison of effectiveness of azilsartan medoxomil and olmesartan in Blacks versus whites with systemic hypertension. Am J Cardiol. 2018;122(9):1496-1505.
  • 6. Williams SF, Nicholas SB, Vaziri ND, Norris KC. African Americans, hypertension and the renin angiotensin system. World J Cardiol. 2014;6(9):878-889.
  • 7. Edarbi [package insert]. Woburn, MA: Azurity Pharmaceuticals, Inc; 2024.

INDICATIONS

EDARBI is a prescription medicine used to treat high blood pressure (hypertension) in adults and EDARBYCLOR is a prescription medicine used to treat high blood pressure (hypertension). Your doctor may prescribe other medicines for you to take along with EDARBI or EDARBYCLOR to treat your high blood pressure. EDARBYCLOR is used when one medicine is not enough or as the first medicine if your doctor decides you are likely to need more than one medicine. Medicines that lower your blood pressure may lower your chances of having a stroke or heart attack, but they don’t work alone. They should be part of a complete treatment plan.

IMPORTANT SAFETY INFORMATION

WARNING: EDARBI® and EDARBYCLOR® can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.
  • Before taking EDARBI or EDARBYCLOR, tell your doctor if you are breastfeeding or plan to breastfeed. Discuss with your doctor other ways to lower your blood pressure. Breastfeeding while taking EDARBI or EDARBYCLOR is not recommended.
  • Do not take EDARBYCLOR if you make less urine because of kidney problems (anuria).
  • Do not take aliskiren-containing products with EDARBI or EDARBYCLOR if you have diabetes.
  • Tell your doctor about all your medical conditions, including if you have heart problems or stroke, have gout, or have liver or kidney problems. Kidney problems may become worse in people that already have kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose or may need to stop treatment with EDARBYCLOR. During treatment with EDARBI or EDARBYCLOR, certain people who have severe heart failure, narrowing of the artery to the kidney, or who lose too much body fluid such as with nausea, vomiting, bleeding, or trauma, may develop sudden kidney failure and in rare instances, death.
  • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other medicines to treat your high blood pressure or heart problem; water pills (diuretics); lithium; or digoxin.
  • EDARBI and EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension) which may cause you to feel faint or dizzy. Vomiting and diarrhea, a low salt diet, sweating a lot, or not drinking enough fluid can also lead to low blood pressure.
  • If you feel faint or dizzy, lie down and call your doctor right away. If you pass out (faint), have someone call your doctor or get medical help. Stop taking EDARBYCLOR.
  • If you have fluid and body salt (electrolyte) problems, tell your doctor if you experience any of the following symptoms: dry mouth, confusion, thirst, lack of energy (lethargic), weakness, drowsiness, passing very little urine or passing large amounts of urine, seizures, muscle pain/cramps, restlessness, muscle tiredness (fatigue), fast or abnormal heartbeat, nausea and vomiting, or constipation.
  • People who have increased levels of uric acid in the blood may develop gout. If you already have gout, tell your doctor about worsening of your gout symptoms.
  • In clinical studies, the most common side effect seen with EDARBI was diarrhea (2.0%).
  • In a clinical study, the side effects seen with EDARBYCLOR included dizziness (8.9%) and tiredness (2.0%).

The Important Safety Information does not include all the information needed to use EDARBI and EDARBYCLOR safely and effectively.

For further information, please see accompanying complete Prescribing Information for EDARBI and EDARBYLCOR.

To report SUSPECTED ADVERSE REACTIONS, contact Azurity Pharmaceuticals, Inc. at 1-800-461-7449 or to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

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