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Risks of uncontrolled high blood pressure

High blood pressure (hypertension) is sometimes called the "silent killer" because there typically are no symptoms. You can't feel it damaging your arteries, heart, or other organs. Over time, however, uncontrolled high blood pressure can cause life-threatening problems.

Heart and artery damage

  • High blood pressure can cause microscopic tears in your artery walls. These tears turn into scar tissue. The scar tissue creates rough walls, collecting cholesterol, platelets, fats, and plaque. This narrows and hardens the arteries
  • Damaged and hardened arteries can limit the amount of blood your organs get, causing them to not work as well as they should
  • Pieces of the deposits left in the arteries due to scar tissue can break off, causing blood clots that flow through the bloodstream until they get stuck in a small space. This can block the blood supply to part of your heart or brain, causing a heart attack or stroke
  • The heart has to work harder to pump blood through damaged arteries. This can make it thicker and larger. The damaged heart works less effectively, so the rest of your organs may not get all the blood they need
  • When the heart doesn't get as much blood as it needs, you could develop angina—uncomfortable pressure, fullness, squeezing, or pain in the center of the chest. People with angina usually feel their symptoms when walking up a hill, climbing stairs, or doing other sorts of physical activity
  • Narrowing of the arteries to your legs, stomach, arms, and head, called peripheral artery disease (PAD), can cause cramping, pain, or tiredness mostly in the leg and hip muscles. People with PAD also have a much higher risk of heart attack or stroke


  • High blood pressure causes your arteries to burst or clog more easily, putting you at high risk for a stroke
  • When a blood vessel in the brain is blocked or bursts, that part of the brain does not get the blood and oxygen it needs. It then starts to die. This can cause you to lose your ability to control movement and body functions, speak, remember things, or think clearly

Kidney damage

  • Your kidneys and your circulatory system are interconnected. The kidneys are full of arteries, and damage to those arteries can make your kidneys lose their ability to filter toxins in the blood and regulate fluid, hormones, acids, and salts in the body
  • Damaged kidneys are also unable to help your body regulate its own blood pressure. Eventually, the damage is so great that the kidneys fail

Vision loss

  • High blood pressure strains delicate blood vessels in the eyes and swells your optic nerve. This leads to impaired vision
  • Permanent vision problems occur when high blood pressure goes untreated. Lowering your blood pressure is the only way to treat the damaged blood vessels in the eye
  • Brain damage caused by stroke can lead to permanent vision loss

Hypertensive crisis

  • Characterized by an extreme and rapid rise in blood pressure (180 or higher systolic or 110 or higher diastolic)
  • May be accompanied by a severe headache, shortness of breath, nosebleed, and/or severe anxiety
  • Blood pressure may reach levels that are damaging to organs
  • Requires immediate medical help via 9-1-1 or in an emergency room

Important Safety Information

WARNING: EDARBI and EDARBYCLOR can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.

  • Before taking EDARBI or EDARBYCLOR, tell your doctor if you are breastfeeding or plan to breastfeed. Discuss with your doctor other ways to lower your blood pressure. Breastfeeding while taking EDARBI or EDARBYCLOR is not recommended.
  • Do not take EDARBYCLOR if you make less urine because of kidney problems (anuria).
  • Do not take aliskiren-containing products with EDARBI or EDARBYCLOR if you have diabetes.
  • Tell your doctor about all your medical conditions, including if you have heart problems or stroke, have gout, or have liver or kidney problems. Kidney problems may become worse in people that already have kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose or may need to stop treatment with EDARBYCLOR. During treatment with EDARBI or EDARBYCLOR, certain people who have severe heart failure, narrowing of the artery to the kidney, or who lose too much body fluid such as with nausea, vomiting, bleeding, or trauma, may develop sudden kidney failure and in rare instances, death.
  • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other medicines to treat your high blood pressure or heart problem; water pills (diuretics); lithium; or digoxin.
  • EDARBI and EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension) which may cause you to feel faint or dizzy. Vomiting and diarrhea, a low salt diet, sweating a lot, or not drinking enough fluid can also lead to low blood pressure.
  • If you feel faint or dizzy, lie down and call your doctor right away. If you pass out (faint), have someone call your doctor or get medical help. Stop taking EDARBYCLOR.
  • If you have fluid and body salt (electrolyte) problems, tell your doctor if you experience any of the following symptoms: dry mouth, confusion, thirst, lack of energy (lethargic), weakness, drowsiness, passing very little urine or passing large amounts of urine, seizures, muscle pain/cramps, restlessness, muscle tiredness (fatigue), fast or abnormal heartbeat, nausea and vomiting, or constipation.
  • People who have increased levels of uric acid in the blood may develop gout. If you already have gout, tell your doctor about worsening of your gout symptoms.
  • In clinical studies, the most common side effect seen with EDARBI was diarrhea (2.0%).
  • In a clinical study, the side effects seen with EDARBYCLOR included dizziness (8.9%) and tiredness (2.0%).

Please talk to your healthcare professional and see complete Prescribing Information for EDARBI and EDARBYCLOR.

You are encouraged to report side effects of prescription drugs to Arbor Pharmaceuticals, LLC Medical Information at 1-866-516-4950 or to the FDA at or call 1-800-FDA-1088.


EDARBI and EDARBYCLOR are prescription medicines used to treat high blood pressure (hypertension). Your doctor may prescribe other medicines for you to take along with EDARBI or EDARBYCLOR to treat your high blood pressure. EDARBYCLOR is used when one medicine is not enough or as the first medicine if your doctor decides you are likely to need more than one medicine. Medicines that lower your blood pressure may lower your chances of having a stroke or heart attack, but they don't work alone. They should be part of a complete treatment plan.