High Blood Pressure
Is Silent.1 But You
Have a Voice.

High Blood Pressure
Is Silent.1 But You
Have a Voice.

What is High Blood Pressure?

What is High Blood
Pressure?

High blood pressure, also called HBP or hypertension, is referred to as the “silent killer” because it often has no warning signs or symptoms.1

But that doesn’t mean you should ignore it. High blood pressure is the leading risk factor for cardiovascular disease–related deaths.2,3 It makes the heart work harder to pump blood, and the constant force of your blood against your artery walls can harden your arteries. This can restrict blood flow and raise your risk of a stroke or heart attack.3

Think of blood pressure as a way to measure your overall heart health. Basically: the lower your blood pressure, the lower your risk.4

If you don’t know your blood pressure numbers, or your cardiovascular risk, talk with your doctor and find out. Together, you can come up with a plan to lower your blood pressure.

Lifestyle changes, dietary changes, and the proper medication are all tools to help you take control of high blood pressure—and silence the silent killer.2,3
Nearly Half of Adults in the U.S. Have High Blood Pressure2,3
45.4% of US adults have HBP.
Under new guidelines, 105.3 million adults in the United States have high blood pressure.2,3* That’s 45.4% of the adult population.
*95% confidence interval of 43.9%-46.9% and 101.9-108.8 million US adults.4
By age 60 or older, about 60% of adults will have HBP.5
Clearly, because high blood pressure is so common, it’s important to monitor and manage—especially as you age.5
*95% confidence interval of 43.9%-46.9% and 101.9-108.8 million US adults.3

What Causes High Blood Pressure?

For most people, there’s no one specific cause of high blood pressure.
However, some factors can increase your chances of developing it:
Age
As we get older, our risk of developing high blood pressure increases.5
Ethnicity
African Americans tend to develop high blood pressure at an earlier age.3
Gender
Men are more likely to get high blood pressure in early adulthood.3 However, as people reach their 60s, high blood pressure is at least as common in women as in men.5
Family history
High blood pressure can run in families.3
Some factors that can contribute to high blood pressure, but haven’t been scientifically proven to cause it, include:
Stress can temporarily raise blood pressure. How you deal with stress may affect other clear risk factors for high blood pressure and heart disease. For example, some people who are experiencing stress make less healthy food choices, put off exercise, smoke, or drink too much.6
Smoking and secondhand smoke temporarily raise blood pressure and damage arteries, increasing the risk for heart disease.6
Sleep apnea, which interrupts your breathing while you sleep, is also a risk factor for high blood pressure.6

What Are the Risks of Uncontrolled High Blood Pressure?6

Even though high blood pressure is silent, you have a voice: little changes can make a big difference. Even reducing your systolic blood pressure by just 2 to 5 mm Hg may lower cardiovascular risks.3* You can’t feel high blood pressure damaging your arteries, heart, or other organs. Over time, however, uncontrolled high blood pressure can cause life-threatening problems.7
*CV risk reduction with EDARBI and EDARBYCLOR has not been established. *CV risk reduction with EDARBI and EDARBYCLOR has not been established.
Click any risk area to uncover more details.
Stroke
Stroke
  • High blood pressure causes your arteries to burst or clog more easily, putting you at high risk for a stroke.7
  • When a blood vessel in the brain is blocked or bursts, that part of the brain does not get the blood and oxygen it needs. It then starts to die. This can cause you to lose your ability to control movement and bodily functions, speak, remember things, or think clearly.8
Vision Loss
Vision Loss
  • High blood pressure strains delicate blood vessels in the eyes and swells your optic nerve. This leads to impaired vision.7
  • Permanent vision problems occur when high blood pressure goes untreated. Lowering your blood pressure is the only way to treat the damaged blood vessels in the eye.7
  • Brain damage caused by stroke can lead to permanent vision loss.7
Angina (Chest Pain)
Angina (Chest Pain)
  • Angina is chest pain, or any other chest discomfort, caused by a lack of blood flow to your heart muscle. It can feel like a pressure or a squeezing in your chest and may even feel like indigestion. But it’s not restricted to your chest only; you might feel it in your shoulders, arms, neck, jaw, abdomen, or back.7
  • It is also possible you may not experience pain. Instead, you may experience symptoms such as shortness of breath, rapid breathing, or fatigue.7
Heart Attack
Heart Attack
  • High blood pressure can cause your heart’s coronary arteries to narrow due to a slow buildup of fat, cholesterol, and other substances collectively referred to as plaque. This slow buildup is commonly known as atherosclerosis.7
  • As your arteries harden with plaque, you’re more likely to develop blood clots. If an artery is blocked by plaque or a clot, nutrients and oxygen can’t reach your heart muscle. When damage or death of part of the heart muscle occurs, it is called a heart attack (myocardial infarction).7
Heart Failure
Heart Failure
  • Heart failure, which may take years to develop, can happen when your heart is unable to provide enough blood to your body. High blood pressure can narrow and block your blood vessels, increasing your risk of developing heart failure.7
  • High blood pressure increases your heart’s workload. With narrower and less elastic arteries, your heart must work harder to pump blood throughout your body.7
  • A higher workload, over time, can enlarge your heart. Your heart thickens and grows to keep up with increased demands. As your heart grows larger, it becomes less efficient at providing your body with oxygen and nutrients.7
Kidney Disease/Failure
Kidney Disease/Failure
  • Your kidneys and your circulatory system are interconnected. The kidneys are full of arteries, and damage to those arteries can make your kidneys lose their ability to filter toxins in the blood and regulate fluid, hormones, acids, and salts in the body.7
  • Damaged kidneys also are unable to help your body regulate its own blood pressure. Eventually, the damage is so great that the kidneys fail.7
Sexual Dysfunction
Sexual Dysfunction
  • In men, high blood pressure can lead to erectile dysfunction. This happens when there’s not enough blood flow to the penis to allow an erection.7
  • In women, high blood pressure can mean loss of libido and interest in sex. This is especially so if the condition is contributing to fatigue. Reduced blood flow to the vagina may also affect how a woman’s body responds before and during intercourse.7
Peripheral Artery Disease
Peripheral Artery Disease
  • Narrowing of the arteries to your legs, stomach, arms, and head, called peripheral artery disease (PAD), can cause cramping, pain, or tiredness mostly in the leg and hip muscles. People with PAD also have a much higher risk of heart attack or stroke.7
Stroke
  • High blood pressure causes your arteries to burst or clog more easily, putting you at high risk for a stroke.7
  • When a blood vessel in the brain is blocked or bursts, that part of the brain does not get the blood and oxygen it needs. It then starts to die. This can cause you to lose your ability to control movement and bodily functions, speak, remember things, or think clearly.8
    • Vision Loss
  • High blood pressure strains delicate blood vessels in the eyes and swells your optic nerve. This leads to impaired vision.7
  • Permanent vision problems occur when high blood pressure goes untreated. Lowering your blood pressure is the only way to treat the damaged blood vessels in the eye.7
  • Brain damage caused by stroke can lead to permanent vision loss.7
    • Angina (Chest Pain)
  • Angina is chest pain, or any other chest discomfort, caused by a lack of blood flow to your heart muscle. It can feel like a pressure or a squeezing in your chest and may even feel like indigestion. But it’s not restricted to your chest only; you might feel it in your shoulders, arms, neck, jaw, abdomen, or back.7
  • It is also possible you may not experience pain. Instead, you may experience symptoms such as shortness of breath, rapid breathing, or fatigue.7
    • Heart Attack
  • High blood pressure can cause your heart’s coronary arteries to narrow due to a slow buildup of fat, cholesterol, and other substances collectively referred to as plaque. This slow buildup is commonly known as atherosclerosis.7
  • As your arteries harden with plaque, you’re more likely to develop blood clots. If an artery is blocked by plaque or a clot, nutrients and oxygen can’t reach your heart muscle. When damage or death of part of the heart muscle occurs, it is called a heart attack (myocardial infarction).7
    • Heart Failure
  • Heart failure, which may take years to develop, can happen when your heart is unable to provide enough blood to your body. High blood pressure can narrow and block your blood vessels, increasing your risk of developing heart failure.7
  • High blood pressure increases your heart’s workload. With narrower and less elastic arteries, your heart must work harder to pump blood throughout your body.7
  • A higher workload, over time, can enlarge your heart. Your heart thickens and grows to keep up with increased demands. As your heart grows larger, it becomes less efficient at providing your body with oxygen and nutrients.7
    • Kidney Disease/Failure
  • Your kidneys and your circulatory system are interconnected. The kidneys are full of arteries, and damage to those arteries can make your kidneys lose their ability to filter toxins in the blood and regulate fluid, hormones, acids, and salts in the body.7
  • Damaged kidneys also are unable to help your body regulate its own blood pressure. Eventually, the damage is so great that the kidneys fail.7
    • Sexual Dysfunction
  • In men, high blood pressure can lead to erectile dysfunction. This happens when there’s not enough blood flow to the penis to allow an erection.7
  • In women, high blood pressure can mean loss of libido and interest in sex. This is especially so if the condition is contributing to fatigue. Reduced blood flow to the vagina may also affect how a woman’s body responds before and during intercourse.7
    • Peripheral Artery Disease
  • Narrowing of the arteries to your legs, stomach, arms, and head, called peripheral artery disease (PAD), can cause cramping, pain, or tiredness mostly in the leg and hip muscles. People with PAD also have a much higher risk of heart attack or stroke.7

    • Know Your Numbers And What They Mean

    MILLIMETERS MATTER

    Blood pressure is measured in millimeters of mercury (mm Hg). It is shown using 2 numbers, one over the other. These millimeters matter, because little changes can make a big difference. Even reducing your systolic blood pressure by just 2 to 5 mm Hg may lower cardiovascular risks.3*

    *CV risk reduction with EDARBI and EDARBYCLOR has not been established.

    Top Number: Systolic Pressure
    This number measures the blood pressure as your heart beats.
    Bottom Number: Diastolic Pressure
    This number measures the blood pressure as your heart relaxes between beats.
    Together, these numbers give a reading of your blood’s force against the walls of your blood vessels. If this reading is high, your blood pressure is likely uncontrolled.
    TO TAKE YOUR BLOOD PRESSURE, REMEMBER
    THE 4 R’s:7
    Reject
    Avoid smoking, exercise, and caffeinated or alcoholic beverages 30 minutes before you take your pressure.
    REST
    Sit calmly in a chair for at least 5 minutes with your arm resting comfortably on a flat surface at heart level.
    relax
    Sit with your feet flat on the floor with your back straight and supported.
    REPEAT
    Each morning before taking medicine and each evening before dinner, take at least 2 readings one minute apart. Record all readings in your blood pressure tracker.

    Managing High Blood Pressure

    Your first step in getting to goal is to understand what high blood pressure means for you. It’s not just about the actual numbers, although they’re very important. It’s about you as a person—your family history, your lifestyle, your food choices, and any other risk factors and conditions you may have.

    Managing your high blood pressure can lower the risk of dying from heart-related problems such as heart attack and stroke.3

    And little changes can make a big difference: Even reducing your systolic blood pressure by just 2 to 5 mm Hg may lower cardiovascular risks.3

    What you can do now:

    Lifestyle Changes
    Lifestyle Changes

    You can help decrease or prevent the negative effects of high blood pressure by adjusting your daily lifestyle and habits, as recommended by your doctor. This includes:

    • Eat a balanced diet. Make it rich in vegetables and fruits.10
    • Get regular physical activity. Aim for 30 minutes a day 5 days a week.7
    • Break the tobacco habit. Avoid all kinds of tobacco, as well as secondhand smoke.7
    • Moderate your alcohol intake. Limit yourself to 2 drinks per day (if you’re a man) or one drink per day (if you’re a woman).7
    • Moderate your sodium intake. Watch out for processed foods, and stay below 1,500 mg per day of sodium.7
    Medical Treatment
    Medical Treatment

    Proper medical treatment and control have been shown to lower the risk of dying from heart-related problems such as heart attack and stroke.2

    You and your doctor can discuss which medicine, or combination of medicines, may work best for you.

    All medicines are just a part of your blood pressure management plan. A complete plan also covers lifestyle, diet, and exercise. Each part of your plan works with the other to help you get to your goal.8

    See How EDARBI® (azilsartan medoxomil)
    & EDARBYCLOR® (azilsartan medoxomil/chlorthalidone)
    Can Help You Take Control

    See How EDARBI® (azilsartan medoxomil)
    & EDARBYCLOR® (azilsartan medoxomil/ chlorthalidone)
    Can Help You
    Take Control

    Learn about EDARBi
    Learn about EDARByclor

    1. High blood pressure: the silent killer. Mayo Clinic. August 28, 2020. Accessed December 17, 2021. https://www.mayoclinichealthsystem.org/hometown-health/speaking-of-health/high-blood-pressure-the-silent-killer
    2. Virani SS, Alonso A, Benjamin EJ, et al. American Heart Association Council on Epidemiology and Prevention Statistics Committee and Stroke Statistics Subcommittee. Heart disease and stroke statistics—2020 update. Circulation. 2020;141(9):e139-e596.
    3. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269-1324.
    4. SPRINT Research Group. Final report of a trial of intensive versus standard blood-pressure control. N Engl J Med. 2021;384(20):1921-1930. doi:10.1056/nejmoa1901281
    5. Franklin SS, Larson MG, Khan SA, et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation. 2001;103(9):1245-1249.
    6. High blood pressure (hypertension) symptoms and causes. Mayo Clinic. Accessed February 1, 2022. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/symptoms-causes/syc-20373410
    7. Health threats from high blood pressure. American Heart Association. Accessed November 12, 2021. https://www.heart.org/en/health-topics/high-blood-pressure/health-threats-from-high-blood-pressure
    8. How high blood pressure can lead to stroke. American Heart Association. Accessed February 1, 2022. https://www.heart.org/en/health-topics/high-blood-pressure/health-threats-from-high-blood-pressure/how-high-blood-pressure-can-lead-to-stroke
    9. Monitoring your blood pressure at home. American Heart Association. Accessed December 1, 2021. https://www.heart.org/en/health-topics/high-blood-pressure/understanding-blood-pressure-readings/monitoring-your-blood-pressure-at-home
    10. Mayo Clinic. 10 ways to control high blood pressure without medication. Accessed December 1, 2021. https://www.mayoclinic.org/diseases-conditions/high-blood-pressure/in-depth/high-blood-pressure/art-20046974

    IMPORTANT SAFETY INFORMATION

    WARNING: EDARBI® (azilsartan medoxomil) and EDARBYCLOR® (azilsartan medoxomil/chlorthalidone) can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.
    • Before taking EDARBI or EDARBYCLOR, tell your doctor if you are breastfeeding or plan to breastfeed. Discuss with your doctor other ways to lower your blood pressure. Breastfeeding while taking EDARBI or EDARBYCLOR is not recommended.
    • Do not take EDARBYCLOR if you make less urine because of kidney problems (anuria).
    • Do not take aliskiren-containing products with EDARBI or EDARBYCLOR if you have diabetes.
    • Tell your doctor about all your medical conditions, including if you have heart problems or stroke, have gout, or have liver or kidney problems. Kidney problems may become worse in people that already have kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose or may need to stop treatment with EDARBYCLOR. During treatment with EDARBI or EDARBYCLOR, certain people who have severe heart failure, narrowing of the artery to the kidney, or who lose too much body fluid such as with nausea, vomiting, bleeding, or trauma, may develop sudden kidney failure and in rare instances, death.
    • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other medicines to treat your high blood pressure or heart problem; water pills (diuretics); lithium; or digoxin.
    • EDARBI and EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension) which may cause you to feel faint or dizzy. Vomiting and diarrhea, a low salt diet, sweating a lot, or not drinking enough fluid can also lead to low blood pressure.
    • If you feel faint or dizzy, lie down and call your doctor right away. If you pass out (faint), have someone call your doctor or get medical help. Stop taking EDARBYCLOR.
    • If you have fluid and body salt (electrolyte) problems, tell your doctor if you experience any of the following symptoms: dry mouth, confusion, thirst, lack of energy (lethargic), weakness, drowsiness, passing very little urine or passing large amounts of urine, seizures, muscle pain/cramps, restlessness, muscle tiredness (fatigue), fast or abnormal heartbeat, nausea and vomiting, or constipation.
    • People who have increased levels of uric acid in the blood may develop gout. If you already have gout, tell your doctor about worsening of your gout symptoms.
    • In clinical studies, the most common side effect seen with EDARBI was diarrhea (2.0%).
    • In a clinical study, the side effects seen with EDARBYCLOR included dizziness (8.9%) and tiredness (2.0%). 

    Please talk to your healthcare professional and see complete Prescribing Information for EDARBI and EDARBYCLOR.

    You are encouraged to report side effects of prescription drugs to Azurity Pharmaceuticals, Inc. Medical Information at 1-866-516-4950 or to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

    INDICATIONS AND USAGE

    EDARBI and EDARBYCLOR are prescription medicines used to treat high blood pressure (hypertension). Your doctor may prescribe other medicines for you to take along with EDARBI or EDARBYCLOR to treat your high blood pressure. EDARBYCLOR is used when one medicine is not enough or as the first medicine if your doctor decides you are likely to need more than one medicine. Medicines that lower your blood pressure may lower your chances of having a stroke or heart attack, but they don't work alone. They should be part of a complete treatment plan.

    EDARBI and EDARBYCLOR are exclusively marketed in the United States by Arbor Pharmaceuticals, LLC, a subsidiary of Azurity Pharmaceuticals, Inc.

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    IMPORTANT SAFETY INFORMATION

    WARNING: EDARBI® (azilsartan medoxomil) and EDARBYCLOR® (azilsartan medoxomil/chlorthalidone) can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.

    IMPORTANT SAFETY INFORMATION

    WARNING: EDARBI® (azilsartan medoxomil) and EDARBYCLOR® (azilsartan medoxomil/chlorthalidone) can cause harm or death to your unborn baby. If you become pregnant while taking EDARBI or EDARBYCLOR, tell your doctor right away. If you plan to become pregnant, talk to your doctor about other treatments to lower blood pressure.
    • Before taking EDARBI or EDARBYCLOR, tell your doctor if you are breastfeeding or plan to breastfeed. Discuss with your doctor other ways to lower your blood pressure. Breastfeeding while taking EDARBI or EDARBYCLOR is not recommended.
    • Do not take EDARBYCLOR if you make less urine because of kidney problems (anuria).
    • Do not take aliskiren-containing products with EDARBI or EDARBYCLOR if you have diabetes.
    • Tell your doctor about all your medical conditions, including if you have heart problems or stroke, have gout, or have liver or kidney problems. Kidney problems may become worse in people that already have kidney disease. If you have kidney problems, you may need blood tests, and your doctor may need to lower your dose or may need to stop treatment with EDARBYCLOR. During treatment with EDARBI or EDARBYCLOR, certain people who have severe heart failure, narrowing of the artery to the kidney, or who lose too much body fluid such as with nausea, vomiting, bleeding, or trauma, may develop sudden kidney failure and in rare instances, death.
    • Tell your doctor about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Especially tell your doctor if you take other medicines to treat your high blood pressure or heart problem; water pills (diuretics); lithium; or digoxin.
    • EDARBI and EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension) which may cause you to feel faint or dizzy. Vomiting and diarrhea, a low salt diet, sweating a lot, or not drinking enough fluid can also lead to low blood pressure.
    • If you feel faint or dizzy, lie down and call your doctor right away. If you pass out (faint), have someone call your doctor or get medical help. Stop taking EDARBYCLOR.
    • If you have fluid and body salt (electrolyte) problems, tell your doctor if you experience any of the following symptoms: dry mouth, confusion, thirst, lack of energy (lethargic), weakness, drowsiness, passing very little urine or passing large amounts of urine, seizures, muscle pain/cramps, restlessness, muscle tiredness (fatigue), fast or abnormal heartbeat, nausea and vomiting, or constipation.
    • People who have increased levels of uric acid in the blood may develop gout. If you already have gout, tell your doctor about worsening of your gout symptoms.
    • In clinical studies, the most common side effect seen with EDARBI was diarrhea (2.0%).
    • In a clinical study, the side effects seen with EDARBYCLOR included dizziness (8.9%) and tiredness (2.0%). 

    Please talk to your healthcare professional and see complete Prescribing Information for EDARBI and EDARBYCLOR.

    You are encouraged to report side effects of prescription drugs to Azurity Pharmaceuticals, Inc. Medical Information at 1-866-516-4950 or to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

    INDICATIONS AND USAGE

    EDARBI and EDARBYCLOR are prescription medicines used to treat high blood pressure (hypertension). Your doctor may prescribe other medicines for you to take along with EDARBI or EDARBYCLOR to treat your high blood pressure. EDARBYCLOR is used when one medicine is not enough or as the first medicine if your doctor decides you are likely to need more than one medicine. Medicines that lower your blood pressure may lower your chances of having a stroke or heart attack, but they don't work alone. They should be part of a complete treatment plan.

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