Take control with a
ARB + diuretic

Take control with a
Powerful ARB + diuretic

EDARBYCLOR® (azilsartan medoxomil/chlorthalidone) is 2 medicines in 1 to help you get to goal. If you’re on 2 or more medications and still short of your blood pressure goal, EDARBYCLOR may be a good fit for you.1 

EDARBYCLOR combines the same active ingredient in EDARBI®, azilsartan medoxomil, with the diuretic (“water pill”) chlorthalidone. (In fact, it’s the only fixed dose combination drug available with chlorthalidone.)2 The ARB in EDARBYCLOR works by relaxing blood vessels, and the diuretic works in the kidneys to help flush excess water and salt (sodium) from the body. Together, these 2 medicines help to lower blood pressure.2 

Abbreviation: ARB, angiotensin II receptor blocker
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I’m not just 169/96.

I’m Glenn.

Every day, people like you are taking control of their high blood pressure with EDARBI and EDARBYCLOR.
See Their Stories
EDARBYCLOR outperforms Similar
Medication in Studies.1*

When scientists compared EDARBYCLOR 40/25 mg with Benicar HCT® (olmesartan medoxomil-hydrochlorothiazide) 40/25 mg for 12 weeks, they found that EDARBYCLOR lowered blood pressure better.1

In fact, EDARByclor demonstrated:

14.5% greater reduction

than Benicar HCT

(-42.5 mm Hg vs -37.1 mm Hg).1

This is important because millimeters matter.
Even a reduction of 2 to 5 mm Hg in your systolic blood pressure may lower your cardiovascular risk.3,4,†

Proper medical treatment and control has been shown to lower the risk of dying from heart-related problems such as heart attack and stroke.3,4†

*Based on clinical trial data vs Benicar HCT® (olmesartan medoxomil-hydrochlorothiazide).1
CV risk reduction with EDARBI and EDARBYCLOR has not been established.

See Study Design

EDARBYCLOR Is Effective for
African American Patients4,5

From a subgroup analysis of the same clinical trial, another benefit of EDARBYCLOR was discovered: It is especially effective at lowering blood pressure among African American patients with high blood pressure. 4,5

EDARByclor demonstrated:

18% greater SBP reduction

than Benicar HCT5*

EDARBYCLOR: -39.3 mm Hg
Benicar HCT: -33.3 mm Hg

This is important because common treatments such as renin angiotensin system (RAS) inhibitors are generally less effective in low-renin populations, including African Americans.6 EDARBYCLOR provides a choice for these populations.5

*Based on clinical trial data vs Benicar HCT, comparing 40/25 dose of EDARBYCLOR to 40/25 mg dose of Benicar HCT among African American participants.5

See Study Design
EDARBYCLOR Safety and Tolerability
Demonstrated safety profile2
and Tolerability
Demonstrated safety profile2

Clinical studies of more than 3,900 people taking EDARBYCLOR found that side effects of the medication were generally mild and transient in nature:

Dizziness in up to 8.9%.2
Fatigue in up to 2.0%.2

Your doctor may monitor the potassium and creatinine levels in your blood while you’re taking EDARBYCLOR.2

EDARBYCLOR may cause serious side effects, including low blood pressure (hypotension), which may cause dizziness or feeling faint.

Vomiting and diarrhea, a low-salt diet, sweating a lot, or not drinking enough fluids can also lead to low blood pressure.7

If you are taking EDARBYCLOR and experience side effects that concern you, call your doctor for medical advice. You are encouraged to report side effects of prescription drugs to Azurity/Arbor Pharmaceuticals, LLC Medical Information at 1-866-516-4950 or to the FDA at www.fda.gov/medwatch or call 1-800-FDA-1088.

Recommended Dosing
The only ARB fixed-dose combination with chlorthalidone2
EDARBYCLOR Recommended
The only ARB fixed-dose combination with chlorthalidone2

EDARBYCLOR is a once-daily oral medication that can help you achieve your blood pressure goals.2

  • May be administered with or without food.
  • May be administered with other antihypertensive agents.
  • Dose may be increased to 40/25 mg after 2 to 4 weeks as needed to achieve BP goals.
  • Correct volume depletion in patients prior to use.
  • Doses above maximum are probably not useful.
40/12.5 mg Once Daily
Starting dose
40/25 mg Once Daily
Maximal dose
Pills are not shown at actual size.

Lower Your BP Numbers, Lower Your Prescription Costs

Get the prescription treatment you need at a cost you can afford with our comprehensive suite of savings programs. Reach your goals by finding the savings program that works for you.

Take control with a powerful ARB8

EDARBI is an effective choice for blood pressure control. EDARBI may be used as a single therapy or in combination with other blood pressure medications.9
Learn about EDARBI

1. Cushman WC, Bakris GL, White WB, et al. Azilsartan medoxomil plus chlorthalidone reduces blood pressure more effectively than olmesartan plus hydrochlorothiazide in stage 2 systolic hypertension. Hypertension. 2012;60(2):310-318. 
2. Edarbyclor [package insert]. Atlanta, GA: Azurity/Arbor Pharmaceuticals, LLC; [2020].
3. Virani SS, Alonso A, Benjamin EJ, et al. Heart disease and stroke statistics-2020 update: a report from the American Heart Association. Circulation. 2020;141(9):e139-e596. doi:10.1161/CIR.0000000000000757
4. Whelton PK, Carey RM, Aronow WS, et al. 2017 ACC/AHA/AAPA/ABC/ACPM/AGS/APhA/ASH/ASPC/NMA/PCNA guideline for the prevention, detection, evaluation, and management of high blood pressure in adults: executive summary: a report of the American College of Cardiology/American Heart Association Task Force on Clinical Practice Guidelines. Hypertension. 2018;71(6):1269-1324.
5. Ferdinand KC, Bakris GL, Cushman WC, et al. Comparison of effectiveness of azilsartan medoxomil and olmesartan in Blacks versus whites with systemic hypertension. Am J Cardiol. 2018;122(9):1496-1505.
6. Williams SF, Nicholas SB, Vaziri ND, Norris KC. African Americans, hypertension and the renin angiotensin system. World J Cardiol. 2014;6(9):878-889. doi:10.4330/wjc.v6.i9.878
7. Low blood pressure — when blood pressure is too low. American Heart Association. Updated October 23, 2016. Accessed December 17, 2021. https://www.heart.org/en/health-topics/high-blood-pressure/the-facts-about-high-blood-pressure/low-blood-pressure-when-blood-pressure-is-too-low
8. White WB, Weber MA, Sica D, et al. Effects of the angiotensin receptor blocker azilsartan medoxomil versus olmesartan and valsartan on ambulatory and clinic blood pressure in patients with stages 1 and 2 hypertension. Hypertension. 2011;57(3):413-420. doi:10.1161/HYPERTENSIONAHA.110.163402
9. Edarbi [package insert]. Atlanta, GA: Azurity/Arbor Pharmaceuticals, LLC; [2020].